(*Corresponding author; undergraduate student author)

Peer-reviewed papers from independent career

  1. Epstein, S. C., Winesett, E. S., Huff, A., Londergan, C.H.*, Charkoudian, L. K.* “Tracking Carrier Protein Motions with Raman Spectroscopy.” Nature Comm., 2019, 10, 2227.
  2. Henry, M., Shorter, S., Charkoudian, L. K., Heemstra, J. M., Corwin, L. A. “FAIL is Not a Four-Letter Word: A Theoretical Framework for Exploring Student Approaches to Academic Challenge and Response to Failure.” CBE Life Sci. Chem. Ed., 2019, 18, ar1-rm1.
  3. Greule, A., Charkoudian, L.K. Cryle, M. J. “Studying Trans-Acting Enzymes that Target Carrier Protein-Bound Amino Acids during Nonribosomal Peptide Synthesis.” Methods in Enzymology, 2019, 617, 114.
  4. Lopes, L. E., Waldis, S. J., Terrell, S. M., Lindgren, K. A.*, Charkoudian, L. K.* “Vibrant Symbiosis: Achieving Reciprocal Science Outreach through Biological Art.” PLoS Biology, 2018, 16(11): e300006.
  5. Rivas, M. A., Courouble, V. C., Baker, M. C., Cookmeyer, D. L., Fiore, K. E., Frost, A. J., Godbe, K. N., Jordan, M. R., Krasnow, E. N., Mollo, A., Nawal, S., Ridings, S. T., Keisuke, S., Shroff, K. D., Studnitzer, B., Thiele, G. A. R., Sisto, A. C., Huff, A. R., Fairman, R., Beld, J., Kokona, B.*, Charkoudian, L. K.* “Type II Polyketide Acyl Carrier Protein Thermostability and Interactions with a Fatty Acid Ketoacyl Synthase.” AIChE Journal. 2018, 64, 4308-4318.
  6. Epstein, S. C., Charkoudian, L. K.*, Medema, M. H.* “A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene Cluster (MIBiG) Repository: Prospects for Research-Based Educational Experiences.” Stand. Genomic Sci., 2018, 13, 16.
  7. Haas, K. L.,* Heemstra, J. M., Medema, M. H., Charkoudian, L. K.* “Collaborating with Undergraduates to Contribute to Biochemistry Community Resources.” Biochemistry, 2018, 57, 383-389.
  8. Cookmeyer, D. L., Winesett, S. E., Kokona, B., Huff, A. R., Aliev, S., Bloch, N. B., Bulos, J. A., Evans, I. L., Farge, C. R., Godbe, K. N., Khromava, M., Konstantinovsky, D. M., Lafrance, A., Lamacki, A. J., Parry, R. C., Quinn, J. M., Thurston, A. M., Tsai, K. J. S., Mollo, A., Cryle, M. J., Fairman, R.*, Charkoudian, L. K.* “ Uncovering Protein-Protein Interactions through a Team-based Undergraduate Biochemistry Course.” PLoS Biology, 2017, 15: e2003145.
  9. Mollo, A., von Krusenstiern, A. N., Bulos, J. A., Ulrich, V., Akerfeldt, K., Cryle, M. J., Charkoudian, L. K.* “P450 Monooxygenase ComJ Catalyses Side Chain Phenolic Cross-linking During Complestatin Biosynthesis.” RSC Advances, 2017, 7, 35376-35384.
  10. Thiele, G. A. R., Friedman, C. P., Tsai, K. J. S., Beld, J., Londergan, C. H.*, Charkoudian, L. K.* “Acyl Carrier Protein Cyanylation Delivers a Ketoacyl Synthase-Carrier Protein Crosslink”.  Biochemistry, 2017, 56, 2533 – 2536.
  11. Finzel, K.*, Beld, J., Burkart, M., Charkoudian, L. K.  “Utilizing Mechanistic Crosslinking Technology to Study Protein-Protein Interactions: An Experiment Designed for an Undergraduate Chemistry Lab.”  J. Chem. Ed. 2017, 94, 375-379.
  12. Kittiä, T., Mollo, A., Charkoudian, L. K.*, Cryle, M. J.* “Have Substrate, will Travel: New Structural Data Reveals the Motion of Carrier Proteins in Non-Ribosomal Peptide Synthesis.”  Angew. Chem. Int. Ed.  2016, 55, 9834 – 9840.
  13. Charkoudian, L. K., Sampson, N. S., Kumar, K., Kritzer, J.* “Designing Convergent Chemistry Curricula.”  Nat. Chem. Biol., 2016, 12, 382 – 386.
  14. Fuga Li, Y., Tsai, K., Harvey, C., Ary, B., Berlew, E., Boehman, B., Findley, D., Friant, A., Gardner, C., Gould, M., Ha, J.H., Lilley, B., McKinstry, E., Nawal, S., Parry, R., Rothchild, K., Silbert, S., Tentilucci, M., Thurston, A., Wai, R., Yoon, Y., Aiyar, R., Medema, M. H., Hillenmeyer, M. E.,* and Charkoudian, L. K.*  “Comprehensive Curation and Analysis of Fungal Biosynthetic Gene Clusters of Published Natural Products.” Fungal Genet. & Biol., 201689, 18-28.
  15. Kokona, B., Winesett, E. S., von Krusenstiern, A. N., Cryle, M. J., Fairman, R.* Charkoudian, L. K.* “Probing the Selectivity of Beta-hydroxylation Reactions in Non-ribosomal Peptide Synthesis using Analytical Ultracentrifugation.” Anal. Biochem2016, 495, 42-51.
  16. Hillenmeyer, M. H.*, Borisova, G. V., Berlew, E. E., Charkoudian, L. K.* “Evolution of Chemical Diversity by Coordinated Gene Swaps in Type II Polyketide Gene Clusters.” Proc. Natl. Acad. Sci. 2015, 112, 13952 – 13957.
  17. Morlon, H., O’Connor, T., Bryant, J. A., Charkoudian, L. K., Docherty, K. M., Jones, E., Kembel, S., Green, J. L., Bohannan, B. J. M.   “The Biogeography of Putative Microbial Antibiotic Production.” PLoS One.  2015, 23, e0130659.
  18. Johnson, M. N. R., Londergan, C. H.*, Charkoudian, L. K.* “Probing the Phosphopantetheine Arm Conformations of Acyl Carrier Proteins using Vibrational Spectroscopy.”  J. Am. Chem. Soc. 2014, 136, 11240-11243.  (Article highlighted in C&EN News).

Peer-reviewed papers from post-doctoral and graduate work

18. Walker, M. C., Thuronyi, B. W., Charkoudian, L. K., Lowry, B., Khosla, C., Chang, C. Y. C.  “Expanding the Fluorine Chemistry of Living Systems using Engineered Polyketide Synthase Pathways.” Science.  2013, 341, 1089-1094.  (Article highlighted in C&EN News and Nature)

19. Fitzgerald, J. T., Charkoudian, L. K., Watts, K. R., Khosla, C. “Analysis and Refactoring of A-74528 Biosynthetic Pathway.” J. Am. Chem. Soc. 2013, 135, 3753-3755.

20. Charkoudian, L. K., Farrell, B. F., Khosla, C.  “Natural Product Inhibitors of Glucose-6-Phosphate Translocase.”  Med. Chem. Comm2012, 3, 926 - 931.

21. Charkoudian, L. K., Liu, C. W., Capone, S., Kapur, S., Cane, D. E., Togni, A., Seebach, D., Khosla, C.  “Probing the Interactions of an Acyl Carrier Protein Domain from the 6-Deoxyerythronolide B Synthase.”  Protein Science.  2011, 20, 1244-1255.

22. Charkoudian, L. K., Fitzgerald, J. F., Khosla, C., Champlin, A.  “In Living Color: Bacterial Pigments as an Untapped Resource in the Classroom and Beyond”.  PLoS Biology, 2010, 8, 10, e1000510.

23. Zaleta, K. R., Charkoudian, L. K., Ridley, C. P., Khosla, C.  “Cloning, Sequencing, Heterologous Expression, and Mechanistic Analysis of A-74528 Biosynthesis.”  J. Am. Chem. Soc. 2010, 132, 9122-9128.

24. Charkoudian, L. K., Dentchev, T., Lukinova, N., Wolkow, N., Dunaief, J. L., Franz, K. J.  “Iron Prochelator BSIH Protects Retinal Pigment Epithelial Cells against Cell Death Induced by Hydrogen Peroxide.  J. Inorg. Biochem2008, 102, 2130-2135.

25. Charkoudian, L. K.*, Heymann, J. J., Adler, M. J., Haas, K. L., Mies, K. A., Bonk, J. F. “Forensics as a Gateway:  Promoting Undergraduate Interest in Science and Graduate Student Pedagogical Development Through a First-Year Seminar Course.”  J. Chem. Ed.  2008, 85, 807 – 812.

26. Charkoudian, L. K., Pham, D. M., Kwan, A., Vangeloff, A. , Franz, K. J.  “Modifications of Boronic Ester Pro-chelators Triggered by Hydrogen Peroxide Tune Reactivity to Inhibit Metal-Promoted Oxidative Stress.  Dalton Trans. 2007, 43, 5031-5042.

27. Charkoudian, L. K., Pham, D. M., Franz, K. J.  “A Pro-chelator Triggered by Hydrogen Peroxide Inhibits Iron-Promoted Hydroxyl Radical Formation.”  J. Am. Chem. Soc.  2006, 128, 12424 – 12425.

28. Franz, K. J., Charkoudian, L. K.  ROS-Sensitive Iron Chelators and Methods of Using the Same.  US Patent 20100004204, 2006.

29. Charkoudian, L.K., Franz, K.J.  “Fe(III) Coordination Properties of Neuromelanin Components:  5, 6- Dihydroxyindole and 5, 6- Dihydroxyindole-2-carboxylic Acid.”  Inorg. Chem. 2006, 45, 3657-3664.